Background: Pityriasis RUBRA PILARIS (PRP) is a rare skin disease characterized by follicular hyperkeratosis and prefollicular erythema with islands of normal skin scattered among erythematous patches with desquamation.Case Report: In this case report, we present a 30-year-old man who developed pityriasis RUBRA PILARIS (PRP) following exposure to dolomite.Conclusion: The diagnosis of PRP was confirmed histologically and the patient was successfully treated with acitretin and cyclosporine.

Circumscribed juvenile pityriasis RUBRA PILARIS (PRP) is a form of PRP that manifests with well defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous skin lesions and follicular hyperkeratotic papules since the age of six years. Skin biopsy was compatible with PRP. He also had hypoparathyroidism and brachyonychia. To our knowledge, this association has not been reported so far.      

Introduction: Palmoplantar keratodermas (PPK) constitute a clinically and genetically complex group of cornification disorders characterized by defective epidermal differentiation leading to marked palmoplantar hyperkeratosis. Classically, keratodermas have been categorised as hereditary and acquired forms. Case Presentation: A 12-year-old male patient presented to our dermatology outpatient department with diffuse thickening and yellowish discoloration of skin over palms and soles since early childhood. He gradually developed progressive thickening and contractures of the fingers of both hands with functional impairment. No such history could be elicited in the family members. Dermatological examination showed bilaterally symmetrical thick hyperkeratotic fissured scaly plaques involving surface of entire palmwith sharp demarcation at volar aspect of wrist. Similar plaques with yellowishhuewere present over the soles with superficial fissures. The histopathological examination of skin biopsy specimen from the palm showed focal parakeratosis alternating with orthokeratosis in both horizontal and vertical directions (checkerboard pattern) with broadened rete ridges. The findings were consistent with pityriasis RUBRA PILARIS (PRP). The patient improved with systemic and topical retinoids. Conclusions: This report focuses on the recognition of unusual presentations of PRP and emphasizes the importance of early diagnosis and timely treatment, which can avert the dreaded morbid and disabling complication of contractures.

Background: Pityriasis RUBRA PILARIS (PRP) is a rare skin disease characterized by follicular hyperkeratosis, perifollicular erythema with islands of normal skin scattered over the sheets of erythroderma, palmoplantar hyperkeratosis and pityriasis capitis with unknown aetiology. Objective: This study has been done in order to determine the demographics, clinical and therapeutic aspects of PRP patients who were admitted to the dermatology ward of Sina Hospital is Hamadan in 1991-1999. Patients & Methods: This was a case series study which the essential information was gathered by referring to the patients files. Then the obtained information was analyzed by SPSS software. Results: As PRP is a rare diseases, only 8 patients were identified. Five of them (61.5%) were men and 3 (37.5%) were women. The highest age of PRP patients was 66 years and the lowest was seven. The mean age of the patients was 32+/- 19.4 years. None of the patients mentioned a positive family history. Six (75%) of the PRP patients suffered from Type I and two patients (25%) from Type III. Five patients (62.5%) were completely, cured, all treated with retinoids, and three patients (37.5%) were partially cured, all treated with methotrexate. There was no case showing failure of the treatment. Conclusion: In this study the number of men was more than women. All of our patients suffered from Type 1 adult onset (classic) or Type III juvenile onset. Retinoids showed more efficacy than methotrexate in the treatment of PRP.      

Papulosquamous disorders constitute one of the common pediatric dermatoses. They are a heterogeneous group consisting of psoriasis, eczema, pityriasis RUBRA PILARIS, and other conditions, where the differential diagnoses are close to each other clinically. Moreover, the presentation of the same disease in children can differ from that occurring in adults. We report two infants with erythematous scaly papules and plaques diagnosed as two different disorders, albeit with a grossly similar appearance. Both these dermatoses are considered to be quite uncommon in infancy and can pose significant challenges in management. These disorders sometimes present with atypical variants, rendering it increasingly difficult to distinguish them. Some of these disorders tend to progress to erythroderma, and the infant may occasionally present directly in the erythrodermic stage, further compounding the conundrum. In such situations, identification of subtle clinical and histopathological clues allows accurate diagnosis, which is imperative for appropriate prognostication and treatment. This article illustrates the importance of histopathology and immunohistochemistry in aiding diagnosis and outlines the management of these disorders while emphasizing the importance of timely intervention in averting inadvertent complications in these young individuals.

Background: Keratosis RUBRA PILARIS is a common condition with an estimated percentage of 40% involvement in the population. This condition is inherited as an autosomal dominant trait and more commonly involves patients with dry skin. In the current study, we evaluated the efficacy of intense pulsed light (IPL) plus ammonium lactate versus ammonium lactate alone in the treatment of keratosis PILARIS. Methods: A total of 50 patches were selected in 10 patients. If there were two similar patches with the same color and same location, each of them was randomized to receive ammonium lactate (Kerapil cream® ) or ammonium lactate (Kerapil cream® ) +IPL. Treatment was performed for 3 months, and improvement was rated by physicians and patients one month and two months after the intervention. Results: The grade of improvement in the IPL + ammonium lactate was not significantly higher than ammonium lactate alone group as rated by blinded physicians at week 4 (P > 0. 05). However, the score of improvement was also higher, as rated by the patients, in the IPL + ammonium lactate versus ammonium lactate alone (P < 0. 05) at week 8. Conclusion: Our results demonstrated that addition of IPL to ammonium lactate could improve the clinical response of keratosis PILARIS lesions.

Background and objectives: Plumeria RUBRA L. (Apocynaceae) is a deciduous shrub or small tree cultivated in subtropical and tropical countries. Its bark is prescribed to treat amoebic dysentery, dropsy, jaundice, scabies, gonorrhea, venereal affections and wounds. In the present research, we aimed to isolate and identify the chemical constituents of the bark of P. RUBRA. Method: An air-dried bark powder of P. RUBRA was exhaustively extracted with methanol. Methanol was removed afterwards under vacuum to get a dark brown mass. The extract was dissolved and adsorbed on silica gel (60-120 mesh) for preparation of slurry. The slurry was loaded over silica gel column packed in petroleum ether. The column was eluted with organic solvents successively in order of increasing polarity to isolate the chemical constituents. The structures of the phytoconstituents, isolated from the plant for the first time, have been elucidated by analyzing the spectral data and on the basis of chemical reactions. Results: Phytochemical investigation of a methanol extract of the stem bark led to isolate n-octyl n-octadecanoate (n-octyl stearate, 1), lauryl-O-α-D-glucopyranosyl– (2ʹ → 1ʹ ʹ )-O-β-D-glucopyranoside (lauryl diglucoside, 2), stearyl-α-L-xylopyranosyl– (2ʹ → 1ʹ ʹ )-α-L-xlyopyranosyl-2ʹ ʹ-(3ʹ ʹ-oxy-4ʹ ʹ ʹ-hydroxy-5ʹ ʹ ʹ-methoxy)-benzoic acid (stearyl dixylosyl methoxygallic acid, 3), vanillic acid 4-O-β-D-arabinopyranosyl-(2a→ 1b)-O-β-D-arabinopyranosyl-(2b→ 1c)-O-β-D-arabino-pyranosyl-(2c→ 1d)-O-β-D-arabinopyranosyl-2d-stearate (vanillic acid 4-O-tetra-arabinosyl stearate, 4), vanillic acid 4-O-β-D-arabinopyranosyl-(2a→ 1b)-β-D-arabinopyranosyl-(2b→ 1c)-β-D-arabino-pyranosyl-(2c→ 1d)-β-D-arabinopyranosyl-(2d→ 1e)-β-D-arabinopyranosyl-(2e→ 1f)-β-D-arabino-pyranosyl-2f-stearate (vanillic acid 4-O-hexa-arabinosyl stearate, 5), β-D-glucopyranosyl-(2a→ 1b)-O-β-D-glucopyranosyl-(2b→ 1c)-O-β-D-glucopyranosyl-(2c→ 1d)-O-β-D-glucopyranosyl-(2d→ 1e)-O-β-D-glucopyranosyl-(2e→ 1f)-O-β-D-glucopyranoside (β-D-hexaglucoside, 6) and β-D-glucopyranosyl-(2a→ 1b)-O-β-D-glucopyranosyl-(2b→ 1c)-O-β-D-glucopyranosyl-(2c→ 1d)-O-β-D-glucopyranosyl-(2d→ 1e)-O-D-glucopyranosyl-(2e→ 1f)-O-β-D-glucopyranosyl-(2f→ 1g)-O-β-D-glucopyranosyl-(2g→ 1h)-O-β-D-rhamnopyranoside (β-D-heptaglucosyl-β-D-rhamnoside, 7). Conclusion: The stem bark of P. RUBRA contained a variety of chemical constituents like a fatty ester, acyl glycosides, vanillic acid glycosides and polyglycosides.